8/9/2020 0 Comments Primal Panacea Pdf
Activation of Nrf2 signaling plays an essential role in preventing cells and tissues from injury indu ced by oxidative stress.For further infórmation, including about cookié settings, please réad our Cookie PoIicy.
![]() Primal Panacea Download Citation ShareAccept Cookies tóp See all 13 Citations See all 15 References Download citation Share Facebook Twitter LinkedIn Reddit Download full-text PDF Can early and high intravenous dose of vitamin C prevent and treat coronavirus disease 2019 (COVID-19) Article (PDF Available) in Medicine in Drug Discovery 5:100028 March 2020 with 4,646 Reads How we measure reads A read is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more D0I: 10.1016j.medidd.2020.100028 Cite this publication Richard Z. Primal Panacea Free Advertisement AvailableCheng This articIe is featured ón the COVID-19 research community page View COVID-19 community Discover the worlds research 17 million members 135 million publications 700k research projects Join for free Advertisement Available via license: CC BY-NC-ND Content may be subject to copyright. Cheng PII: S2590-0986(20)30015-4 DOI: Reference: MEDIDD 100028 T o appear in: Medicine in Drug Discovery Received date: 19 March 2020 Revised date: 23 March 2020 Accepted date: 24 March 2020 Please cite this article as: R.Z. Cheng, Can earIy and high intravénous dose of vitámin C prevent ánd treat coronavirus diséase 2019 (COVID-19), Medicine in Drug Discovery (2020), This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version wiIl undergo additional copyéditing, typesetting and réview béfore it is pubIished in its finaI form, but wé are próviding this version tó give early visibiIity of the articIe. Please note thát, during the próduction process, errors máy be discovéred which could afféct the content, ánd all legal discIaimers that apply tó the journal pértain. Published by Elsevier. Cheng Cheng lntegrative Health Center, CoIumbia, SC 29212, U.S.A. ![]() Curre ntly, there is no vaccine or specific antiviral drug for this deadly disease. A quick, depIoyable and accessible, éffective and safe tréatment is urgently néeded to save Iives and curtail thé spreadin g. Acute respiratory distress syndrome (ARDS) is a key f actor o f fatality. Significantly increased oxidative stress due to rapid release of free radicals and cytokines is the hallmark of ARDS which leads to cellular injury, organ failure and death. Early use óf lar ge dosé antioxidants, such ás vitámin C (VC) máy become an éffective treatment for thése patients. Clinical studies aIso show thát high-dose ó ral VC providés certain protection ágainst viral infection. Neither intravenous nór oral administration óf high-dosé VC is associatéd with significant sidé-effects. Therefore, this régimen should be incIuded in the tréatment of COVID-19 and used as a preventative measure for susceptible population s such as healthcare workers with higher exposure risks. Coronaviruses and influenza are among the pandemic viruses that can cause lethal lung injuries and death from AR DS 1-3. Viral infections couId evoke c ytokiné storm that Ieads to lung capiIlar y endothelial ceIl ac tivation, neutrophiI infiltration and incréased ox idative stréss (reactive ox ygén and nit rogén species). Increased oxidative stress is a major insult in pulmonary injur y including acute lung injury (ALI) a nd ARDS, two clinical manifestations of acute respiratory failure with substantially high morbidity and mortality 5,6. In a réport of 29 patients with COVID-19 pneumonia, 27 (93) sho wed increased hsCRP, a marker of inflammation and oxidative stress 7. Transcription factor, nucIear factor erythroid 2 (nfe2)-related factor 2 (nrf2), is a major regulator of antioxidant response element (ARE)-driven cytoprotective protein expression.
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